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"Walk it off, Sally": Why Exercise Helps Speed Injury Recovery
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August 15, 2010
5:46 pm
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Caution: contains SCIENCE

Robert H. Demling, MD. The Role of Anabolic Hormones for Wound Healing in Catabolic States. J Burns Wounds. 2005; 4: e2.

"There is a well-recognized interrelationship between hormones, nutrition, and wound healing. The anabolic process of protein synthesis, with new tissue formation, requires the action of anabolic hormones. Exogenous administration of these agents has been shown to maintain or increase lean body mass as well as directly stimulate the healing process through their anabolic and anticatabolic actions." [emphasis mine]

Note the word "required." That is a very strong word in the scientific literature. Anabolic hormones like testosterone*, growth hormone, and IGF-1 are…

June 3, 2011
4:58 pm
downtownj
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Succinct and well put. Broke my wrist hooping. Time to start sprinting it seems. Thanks for the great post. Very glad I found this resource.

June 3, 2011
5:39 pm
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downtownj:

I've since learned that it's also helpful to take a hot shower, or even hot tub it, after exercise, as it raises hGH levels.  See http://www.ncbi.nlm.nih.gov/pubmed/12713511

I hope your recovery is quick and complete. Feel free to stick around!

JS

October 10, 2011
1:02 pm
Scotlyn
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Very interesting post. The heat link in your comment may show the basis (in terms of clinical observation) for the strong preference TCM practitioners have for applying heat rather than cold to injuries. They often cite the classical teaching that application of cold to an injury will make it chronic and long-lasting, while heat promotes healing, and are generally not too impressed with the I (ice) part of the R.I.C.E. protocol taught in First Aid classes.

October 10, 2011
11:21 pm
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Scotlyn:

I agree: RICE is stupid unless you have a muscle hematoma, and even then you only ice until the swelling is no longer critical.

How is tissue damage supposed to heal without blood flow?  Inflammation is the body's healing response.  Sheesh.

MEAT is better than RICE (Google it).

JS

March 8, 2012
8:04 pm
Kate
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I've heard a defense of icing an injury that takes into account the fact that inflammation is a natural healing response. Not very detailed, but it goes like this: the inflammation is step 1 of the body's healing process, but the body also needs to get to step 2 and onward. In the case of recurring strain or inflammation that lasts longer than optimal ("optimal" seems to depend on the location and severity of the injury), inflammation needs to be controlled because the good intentions of the body will at this point be doing harm by keeping the injured site from progressing to later steps of healing. For example, I sprained my wrist last fall and wouldn't have needed to ice it if it hadn't been a very inconvenient sprain which I kept reinjuring for months, doing things like itching my elbow and picking up objects heavier than a few pounds. The inflammation from the recurring injury was supposedly preventing further healing after the initial inflammation had done its job.

This all makes sense to me. Thoughts, anyone?

March 9, 2012
1:26 am
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Kate:

I think that if you're constantly reinjuring, it's time for the old joke: "Stop doing that, then."  Braces can be helpful, if only as a reminder not to use that body part!

There is some merit to the idea of occasional, short-duration icing (15 minutes), as it can temporarily increase blood flow after you take the ice off.  Alternating ice and heat would be even better, but cold is more difficult to work with logistically.  I just tie a heating pad around the affected area while I'm working.

JS

March 29, 2012
3:07 pm
Mitchell
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The method I've learned is 'PRINCE' or
Protect, Rest, Ice, NSAIDs, Compression, Elevation

I'll outline the steps quickly, and maybe that will give you a better idea of why icing a injury is good.

Protect - prevent further injury

Rest - stop moving the area and let it rest to reduce swelling.

Ice : ice causes the tissue to contract, which prevents excess swelling. You only want to do this for a 10-15 minutes every two to three hours for the first 2 days following a strain or sprain.

NSAIDs - non-steroidal anti-inflammatory drugs, like ibuprofen and aspirin that will stop the pain but also reduce swelling to accelerate healing

Compression - wrap injury to reduce swelling

Elevation - lift above heart-level so that excess fluid can drain via gravity, especially useful during sleep when you cannot apply ice yourself.

---

Now thats for immediate action over the course of maybe a week after a serious injury.

Exercise as you've mentioned is great for helping an injury along. This is because your pumping new blood into the area (and more of it).

Heat works along the same lines, the local capillaries naturally expand and enlarge, which lets even more blood into the area.

The oxygen and nutrient-rich blood is possibly the most necessary ingredient for a speedy recovery.

Now, you've mentioned alternating hot and cold - this is good for a specific reason. You said that taking it off can increase blood flow, and thats true.

When you alternate, it increases the blood flow even more, and prevents the body getting used to the hot temperature. This ensures that applying the heat is effective, even if you've been doing it for a while.

HOWEVER make sure that your only applying heat AFTER inflammation and swelling has left the area, because otherwise heat will only cause MORE swelling.

Hopefully this explains the role of icing an injury, and why heat therapy is so great.

- on another note, great blog, I've just started reading your book now!

March 29, 2012
11:52 pm
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Mitchell:

That's a good summary of the traditional treatment.  

I'm not a fan of compression.  Isn't icing supposed to prevent the damage done by compression?  (i.e. the swelling prevents blood and lymph from moving through the area)  If so, then why would anyone want to compress the area deliberately?  Again, in the case of a hematoma, I understand: I'm bleeding internally, and I need to control the bleeding.  But in the case of anything else, it seems like compression is causing the very problem we're trying to prevent by icing.

Furthermore, swelling usually isn't a big issue for the injuries we're most concerned about (tendon/ligament strains, sprains, or snaps).  Yet doctors and therapists alike continue to recommend a treatment that decreases circulation and slows healing in these cases.

Finally, acute phase inflammation isn't bad!  It's a necessary part of the immune response leading to tissue remodeling and eventual recovery.  I have no idea why anyone would want to abort it unless the swelling is cutting off circulation; I have no idea why anyone would want to simulate the cutting off of circulation by compressing and elevating the affected area; and as the acute phase of inflammation lasts perhaps a few days, RICE for a week is far overshooting the mark (and dramatically inhibiting the healing response) even if you still believe it's necessary to 'control' the acute phase.

Further reading:

Rice or Meat For Acute Ligament Sprain Treatment?

JS

February 3, 2013
3:53 am
paleodoc
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Applying the RICE principal has more to do with pain relief than accelerating healing. Moreover, it depends on the severity of the injury. An inversion injury to the ankle can result in a minor sprain or joint subluxation or disruption. Resting is more important in the latter than the former. Ice and elevation can help to reduce pain in the injured limb during the first few days after injury, but may not optimize the rate of healing. But I don't think it retards healing either.

February 5, 2013
12:44 pm
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paleodoc:

"Applying the RICE principal has more to do with pain relief than accelerating healing."

That's a good point.  There's also some interesting research showing that popping lots of OTC anti-inflammatories substantially inhibits the healing process.

The best results I've obtained when dealing with my own injuries have been when I skipped RICE and went directly for MEAT.  Maybe I have a greater pain tolerance than others...?

JS

October 24, 2014
3:51 pm
Step
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Both compression and ice work similarly. They both reduce inflammation which retards healing. Body has to get out damage tissue and debre and in return it must get in nutrients and oxygen for repair. Inflammation slows all of that. I have never seen inflammation helping me in any way and don't know why the body does it. I use compression on all minor injuries with my hands and it does wonders. For example when a hammer feel off a tall ladder on my head it nearly knocked me out but by hard pressure to the bump that was forming till I hardly felt pain and then released the pressure, it hardly hurt and healed very fast. Great for when a kid gets their finger jammed in a closing door, just hold the finger tight till the pain goes away. Ice works as well when applied immediately after the injury. Hot cold water treatment goes back 100's of years as a time tested way of healing much faster.

October 25, 2014
8:30 am
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Step:

Acute inflammation due to injury (e.g the first few days) is a necessary part of the healing process! It 'marks' the damaged tissue and begins to scavenge it so it can be replaced with new, undamaged tissue. Stopping acute inflammation basically short-circuits everything. See, for instance:

J Physiol. 2007 Jan 1;578(Pt 1):327-36. Epub 2006 Oct 12.
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo.
Tidball JG1, Wehling-Henricks M.
http://www.ncbi.nlm.nih.gov/pubmed/17038433

The place compression actually does some good is, as you point out:
1. A hematoma, where excessive swelling can actually inhibit blood flow, AND
2. Immediately after the injury.
After that, you're just cutting off circulation and thereby retarding the process.

Pressure vs. pain, OTOH, is simply a distraction, though an often effective one.

JS

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