Still haven't found "the answer." I lost 100 lbs on a low-carb diet in 1999 (actually 130, but re-gained 30). Having low-fat-dieted myself all the way to 350 lbs, losing that much and keeping most of it off for a dozen years has been relatively easy. What has *not* been easy is getting rid of the remaining 50+ lbs I need to lose (for several reasons, including Obstructive Sleep Apnea). I can struggle my way down to around 240, and then the weight seems to just re-attach itself despite my almost religious avoidance of carbohydrate. I'm down close to eating only meat (and some supplements, mostly minerals, but including Vitamin C, D, & K), yet the weight will not budge below 240.

I keep reading all of this talk about leptin, and impaired metabolism of former fatties. That's all good information, but what I'm looking for is HOW DO I FIX IT?

Fascinating article! (found it through Peter's blog). I have to add a comment from a different angle: our ability to oxidize stored and dietary fat is limited not only for people with metabolic syndrome but for everyone - except those limits are vastly different! Chris Masterjohn posted a very interesting article touching this aspect (read also my comment there underneath). One of the limiting factors seems to be the cellular and immune system's ability to handle metabolic byproducts, involving glutathione.

An upper limit on fat on a high animal fat LC diet (like the one I am on since 1999) could be an important factor preventing some people from effectively using such a diet for healing themselves. For most people such limit is well below satiety threshold, that is you would first stop eating fat (i.e. try overeating butter!) before you manage to overeat it, but for some this limit is so small (initially) that overeating may happen.

It would be very interesting and useful (if you have means) conduct more thorough study on what that limit exactly is for different groups of patients and what is a typical time-frame for the limit to increase. For example in my case it was 2 months (I was 43 at the time with some metabolic syndrome). I knew of people (very rarely) who had to abandon a high fat diet after several months to a couple of years due to that effect.

Regards,
Stan (Heretic)

[...] Debattens vågor fortsätter att gå höga om vad som egentligen gör oss feta (typ debatten mellan Taubes och Guyenet) och flera kunniga personer har kommit med intressanta inlägg. Ett av de senaste, av J Stanton på gnolls.org, är mycket intressant: When Satiety Fails: Why Are We Hungry? Part IV. [...]

[...] steps forward in the obesity discussion: Peter at Hyperlipid is following up on JS Stanton’s lead regarding mitochondrial dysfunction in obesity. CarbSane chips in with evidence for metabolic [...]

[...] When Satiety Fails: Why Are We Hungry? Part IV [...]

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